The Infrastructure Layer for Human-Relevant Medicine
Digital twins, organoids, and AI converge to transform drug discovery under the FDA Modernization Act
Human Simulation Stack
The convergence of biology, computation, and engineering for predictive medicine
Digital Twins
Computational models of individual patients for personalized drug response prediction and treatment optimization.
Organoids
Patient-derived 3D cellular models that replicate organ function for disease modeling and drug testing.
Organ-on-Chip
Microfluidic devices that recreate the physiological environment of human organs for drug safety assessment.
AI-Driven Discovery
Machine learning platforms that accelerate target identification and optimize drug candidates.
The Building Blocks of Life
Real protein structures from the Protein Data Bank powering next-generation drug discovery
DNA Double Helix
The canonical B-form DNA structure - foundation of genetic medicine and CRISPR therapeutics
SARS-CoV-2 Spike
COVID-19 spike protein - target of mRNA vaccines and monoclonal antibody therapies
Structures courtesy of RCSB Protein Data Bank (rcsb.org) · View Interactive Models
A New Foundation for Human Simulation
A Patient Analog is the unified biological-computational representation of human physiology, integrating organoids, microphysiological systems, organ-on-chip platforms, multi-omics, and simulation engines into a single modeling substrate.
This hierarchy progresses from biological substrates to fully integrated, simulation-ready human models — establishing the foundational infrastructure that will define the next era of drug discovery and precision medicine.
- The Human The biological reality above all modeling frameworks
- Patient Analog Integrated bio-digital model of complete human
- Digital Twin Computational patient simulation platform
- System Analog Multi-organ physiological subsystems
- Organ Analog Individual organ modeled at high fidelity
- Tissue / MPS Engineered microphysiological systems
- Organoid 3D cell cultures mimicking organ structure
Referenced for educational context. Not affiliated with or endorsed by these institutions.
Intelligence Hub
500+ curated research links covering regulatory, scientific, and industry resources
Regulatory
FDA, NIH, EMA guidance and legislation including Modernization Act 2.0/3.0
45+ sourcesScientific
Organ-on-chip, organoids, digital twins, and MPS research platforms
120+ sourcesIndustry
Leading companies in human simulation technology and drug discovery
85+ sourcesAI & Compute
Quantum computing, machine learning, and computational biology resources
50+ sourcesOrgan-on-Chip
- Engineering liver organoids-on-a-chip for toxicity screeningFrontiers
- Lung-chip model recreates COPD inflammationNature
- Microfluidic platforms advance personalized medicineLab Chip
Organoid Research
- Brain organoids reveal autism gene functionCell
- Patient-derived organoids predict chemo responseScience
- Retinal organoids restore partial vision in trialsNature Med
Digital Twin
- Virtual patient models predict cardiac drug effectsSci Rep
- AI-powered digital twins enter clinical trialsTechCrunch
- DARPA funds next-gen human simulation platformDefense
Regulatory Updates
- FDA accepts first NAMs-only drug applicationFDA.gov
- EMA releases 3Rs implementation guidanceEMA
- NIH NCATS expands tissue chip program fundingNIH
Drug Discovery
- AI discovers novel antibiotic compound in 48 hoursNature
- Pfizer partners with organ-chip startupReuters
- Phase 3 trial uses organoid-guided dosingEndpoints
Industry News
- Emulate raises $82M Series E for organ-chipsTechCrunch
- Roche acquires AI drug discovery platformBioPharma
- Organoid biobank startup valued at $500MFierceBio
Science Lab Games
Educational simulations exploring organ-on-chip, organoids, and drug discovery
Science Lab
6 interactive simulations: Lung-on-Chip, PK Digital Twin, Kidney Nephron, RNA Structure
Kenneth's Biotech
Educational puzzle game with 50+ modules and 24 levels
Kids Zone
Quizzes and games for young scientists learning about biotech
Lung-on-Chip
Control airflow and maintain oxygen exchange in a breathing simulation
Drug Predictor
Digital twin simulation for predicting drug responses
Kidney Filtration
Filter waste molecules while preserving nutrients
Explore the Future of Medicine
Interactive simulations, live research feeds, and comprehensive resources for human-relevant drug discovery.