2012
Nobel Prize
Yamanaka
Any
Cell Type
Differentiation
Patient
Specific
Genetics
8
Scalable
Expansion
Induced pluripotent stem cells (iPSCs) can be generated from any patient and differentiated into any cell type, enabling creation of patient-specific disease models. This technology underlies most organoid and organ-chip platforms, providing human-relevant, genetically-defined cells for drug discovery.
DERIVED CELL TYPES
Cardiomyocytes
Cardiac safety; beating cells; electrophysiology
Neurons
CNS diseases; motor neurons; cortical
Hepatocytes
Liver toxicity; metabolism; DILI
Beta Cells
Diabetes; insulin secretion
Immune Cells
Macrophages; T cells; NK cells
Epithelial
Lung; kidney; intestinal